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1

Inhibition of KCNQ2/3 channels by HN38 and XE991 depends on the conformation of the outer vestibule

Rodier, Elizabeth, Niday, Zachary, Doci, Klarita, Wang, Lei, Nan, Fa-Jun, Gao, Zhao-Bing, Tzingounis, Anastasios V

Journal:

Molecular Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

2

Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius

Sheng-Ping Yang, Zhao-Bing Gao, Yan Wu, Guo-Yuan Hu, Jian-Min Yue

Journal:

Year:

2008

Language:

english

File:

PDF, 504 KB

english, 2008

3

Electrophysiological characterization of a novel Kv channel blocker N, N′-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesulfonamide found in virtual screening

Zhao-bing GAO, Xue-qin CHEN, Hua-liang JIANG, Hong LIU, Guo-yuan HU

Journal:

Acta Pharmacologica Sinica

Year:

2008

Language:

english

File:

PDF, 716 KB

english, 2008

4

Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons

Zhao-Bing Gao, Guo-Yuan Hu

Journal:

Year:

2005

Language:

english

File:

PDF, 212 KB

english, 2005

5

Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus

Zhao-Bing Gao, Xue-Qin Chen, Guo-Yuan Hu

Journal:

Year:

2006

Language:

english

File:

PDF, 344 KB

english, 2006

6

Discovering Potassium Channel Blockers from Synthetic Compound Database by Using Structure-Based Virtual Screening in Conjunction with Electrophysiological Assay

Liu, Hong, Gao, Zhao-Bing, Yao, Zhiyi, Zheng, Suxin, Li, Yang, Zhu, Weiliang, Tan, Xiaojian, Luo, Xiaomin, Shen, Jianhua, Chen, Kaixian

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 472 KB

english, 2007

7

Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis

Liu, Hong-Bing, Zhang, Hua, Li, Ping, Gao, Zhao-Bing, Yue, Jian-Min

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 507 KB

english, 2012

8

Kv1.2 potassium channel inhibitors from Chukrasia tabularis

Liu, Hong-Bing, Zhang, Hua, Li, Ping, Wu, Yan, Gao, Zhao-Bing, Yue, Jian-Min

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 420 KB

english, 2012

9

Chlorahololides A and B, Two Potent and Selective Blockers of the Potassium Channel Isolated from Chloranthus holostegius

Yang, Sheng-Ping, Gao, Zhao-Bing, Wang, Fang-Dao, Liao, Shang-Gao, Chen, Hua-Dong, Zhang, Chuan-Rui, Hu, Guo-Yuan, Yue, Jian-Min

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

10

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

Zhou, Ping-zheng, Babcock, Joseph, Liu, Lian-qing, Li, Min, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2011

Language:

english

File:

PDF, 612 KB

english, 2011

11

Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels

Li, Ping, Sun, Hai-feng, Zhou, Ping-zheng, Ma, Chao-ying, Hu, Guo-yuan, Jiang, Hua-liang, Li, Min, Liu, Hong, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

12

Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels

Hu, Hai-ning, Zhou, Ping-zheng, Chen, Fei, Li, Min, Nan, Fa-jun, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2013

Language:

english

File:

PDF, 926 KB

english, 2013

13

Identification and Evaluation of Antiepileptic Activity of C 21 Steroidal Glycosides from the Roots of Cynanchum wilfordii

Li, Jin-Long, Gao, Zhao-Bing, Zhao, Wei-Min

Journal:

Journal of Natural Products

Year:

2015

Language:

english

File:

PDF, 631 KB

english, 2015

14

Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques

Yue, Jin-feng, Qiao, Guan-hua, Liu, Ni, Nan, Fa-jun, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2016

Language:

english

File:

PDF, 958 KB

english, 2016

15

Ion channels research in the post-genomic era

Attali, Bernard, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2016

Language:

english

File:

PDF, 163 KB

english, 2016

16

Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Anti-Nociceptive Efficacy

Sun, Hao, Shi, Min, Zhang, Wei, Zheng, Yue-Ming, Xu, Yazhou, Shi, Jun-Jie, Liu, Ting, Gunosewoyo, Hendra, Pang, Tao, Gao, Zhao-Bing, Yang, Fan, Tang, Jie, Yu, Li-Fang

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 738 KB

english, 2016

17

The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7

Zhang, Wen-Ming, Yang, Teng, Pan, Xue-Ying, Liu, Xin-Lan, Lin, Hai-Xia, Gao, Zhao-Bing, Yang, Cai-Guang, Cui, Yong-Mei

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 792 KB

english, 2016

18

Two novel C 18 -diterpenoid alkaloids, sinomontadine with an unprecedented seven-membered ring A and chloride-containing sinomontanine N from Aconitum sinomontanum

Zhang, Qin, Tan, Jun-Jie, Chen, Xue-Qin, Gao, Zhao-Bing, Jia, Qi, Chen, Kai-Xian, Li, Yi-Ming

Journal:

Tetrahedron Letters

Year:

2017

Language:

english

File:

PDF, 1021 KB

english, 2017

19

Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802

Zheng, Yue-ming, Wang, Wan-fu, Li, Yan-fen, Yu, Yong, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

20

The synthesis and antistaphylococcal activity of N -sulfonaminoethyloxime derivatives of dehydroabietic acid

Zhang, Wen-Ming, Yao, Yang, Yang, Teng, Wang, Xue-Ying, Zhu, Zhen-Yun, Xu, Wen-Tao, Lin, Hai-Xia, Gao, Zhao-Bing, Zhou, Hu, Yang, Cai-Guang, Cui, Yong-Mei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 557 KB

english, 2018

21

Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels

Li, Yan-fen, Zheng, Yue-ming, Yu, Yong, Gan, Yong, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2018

Language:

english

File:

PDF, 1.76 MB

english, 2018

22

Discovery of novel retigabine derivatives as potent KCNQ4 and KCNQ5 channel agonists with improved specificity

Wang, Lei, Qiao, Gua-Hua, Hu, Hai-Ning, Gao, Zhao-Bing, Nan, Fa-Jun

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 808 KB

english, 2018

23

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Wang, Jin-tao, Zheng, Yue-ming, Chen, Yue-ting, Gu, Min, Gao, Zhao-bing, Nan, Fa-jun

Journal:

Acta Pharmacologica Sinica

Year:

2019

Language:

english

File:

PDF, 1.92 MB

english, 2019

24

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Wang, Jin-tao, Zheng, Yue-ming, Chen, Yue-ting, Gu, Min, Gao, Zhao-bing, Nan, Fa-jun

Journal:

Acta Pharmacologica Sinica

Year:

2019

File:

PDF, 1.92 MB

2019

25

Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels

Xie, Zhu-qing, Tian, Xiao-ting, Zheng, Yue-ming, Zhan, Li, Chen, Xue-qin, Xin, Xiao-ming, Huang, Cheng-gang, Gao, Zhao-bing

Journal:

Acta Pharmacologica Sinica

Year:

2020

File:

PDF, 1.33 MB

2020

26

Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors

Xiang, Hao-Yue, Wang, Xiang, Chen, Yan-Hong, Zhang, Xi, Tan, Cun, Wang, Yi, Su, Yi, Gao, Zhi-Wei, Chen, Xiao-Yan, Xiong, Bing, Gao, Zhao-Bing, Chen, Yi, Ding, Jian, Meng, Ling-Hua, Yang, Chun-Hao

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.48 MB

2020

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